Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.570


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU5F1chr6_-_312425930.411.1e-01Click!
SOX2chr3_+_182912405-0.411.2e-01Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_74493918 11.662 ALB
albumin
chr4_+_74493174 10.931 ALB
albumin
chr4_+_74493331 9.295 ALB
albumin
chr2_-_215949566 8.821 FN1
fibronectin 1
chr4_+_74493266 8.808 ALB
albumin
chr10_+_7785235 8.096 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785331 7.940 ITIH2
inter-alpha (globulin) inhibitor H2
chr4_+_74493218 7.870 ALB
albumin
chr10_+_7785360 7.796 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785290 7.622 ITIH2
inter-alpha (globulin) inhibitor H2
chr17_+_24394281 7.344 PIPOX
pipecolic acid oxidase
chr4_+_100714995 6.744 MTTP
microsomal triglyceride transfer protein
chr17_+_24394043 6.035 NM_016518
PIPOX
pipecolic acid oxidase
chr16_-_54424517 5.217 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr12_-_9123126 5.156 A2M
alpha-2-macroglobulin
chr4_+_74493301 5.014 ALB
albumin
chr7_+_45899080 4.221 IGFBP1
insulin-like growth factor binding protein 1
chr10_+_4995685 4.077 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr8_-_17797127 4.069 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr7_+_45899621 3.974


chr10_-_5035967 3.754 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr4_-_187881977 3.674 NM_005245
FAT1
FAT tumor suppressor homolog 1 (Drosophila)
chr4_+_74500748 3.596 ALB
albumin
chr4_-_110942783 3.422 NM_000204
CFI
complement factor I
chr16_+_70646008 3.375 NM_001126102
NM_005143
HP

haptoglobin

chr13_+_96592051 3.183 MBNL2
muscleblind-like 2 (Drosophila)
chr10_+_4995597 3.158 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr13_-_47885018 3.050 LPAR6
lysophosphatidic acid receptor 6
chr10_-_52315436 3.047 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr10_+_4995453 2.935 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr2_-_21079145 2.719 APOB
apolipoprotein B (including Ag(x) antigen)
chr19_-_53081326 2.684 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr2_+_138438277 2.613 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr10_+_7785347 2.532 ITIH2
inter-alpha (globulin) inhibitor H2
chr7_+_94130752 2.523 PEG10
paternally expressed 10
chr11_+_69165119 2.451 CCND1
cyclin D1
chr11_+_69165018 2.338 NM_053056
CCND1
cyclin D1
chr9_-_74757735 2.274 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chrX_-_100920493 2.170 GK
glycerol kinase
chr10_+_114123765 2.161 ACSL5
acyl-CoA synthetase long-chain family member 5
chr7_+_94130673 2.101 PEG10
paternally expressed 10
chr18_-_3001944 2.022 NM_014646
LPIN2
lipin 2
chr7_+_29486010 2.020 NM_001039936
CHN2
chimerin (chimaerin) 2
chr3_-_150422474 1.948 NM_000096
CP
ceruloplasmin (ferroxidase)
chr10_+_124141808 1.779 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr10_-_69267774 1.742 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr12_-_121753795 1.702 NM_177551
GPR109A
G protein-coupled receptor 109A
chr15_+_22652790 1.598 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr15_+_22619886 1.521 NM_022806
NM_022807
NM_022808
SNRPN


small nuclear ribonucleoprotein polypeptide N


chr2_-_188127430 1.513 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr1_+_165564904 1.508 NM_001198783
POU2F1
POU class 2 homeobox 1
chr10_+_114123828 1.489 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr4_+_140806536 1.478 MGST2
microsomal glutathione S-transferase 2
chr6_-_138862273 1.455


chr9_-_115877104 1.389 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_+_123744131 1.380 TACC2
transforming, acidic coiled-coil containing protein 2
chr12_-_121767272 1.364 NM_006018
GPR109B
G protein-coupled receptor 109B
chr4_+_74520796 1.356 NM_001134
AFP
alpha-fetoprotein
chr2_+_228386800 1.327 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr18_+_27425727 1.311 NM_000371
TTR
transthyretin
chr21_+_39117064 1.261 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr4_+_140806371 1.243 NM_002413
MGST2
microsomal glutathione S-transferase 2
chr5_-_95184121 1.243 GLRX
glutaredoxin (thioltransferase)
chr1_-_41398126 1.195 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr2_+_128644510 1.153 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr4_-_155731288 1.135 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr2_+_113601608 1.079 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr5_-_95184221 1.076 NM_001118890
NM_002064
GLRX

glutaredoxin (thioltransferase)

chr15_+_22772545 1.072 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr2_+_113601616 1.051 IL1RN
interleukin 1 receptor antagonist
chr3_-_150578103 1.048 TM4SF1
transmembrane 4 L six family member 1
chr2_+_211166323 1.043 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr1_+_112740378 1.043


chr2_+_99163968 1.035 NM_145212
MRPL30
mitochondrial ribosomal protein L30
chr2_-_188086612 1.032 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr5_+_76150588 1.031 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr5_+_176449156 1.011 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr1_+_165565006 1.001 POU2F1
POU class 2 homeobox 1
chr11_+_69165159 0.998 CCND1
cyclin D1
chr6_-_47362102 0.983 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr3_+_12367993 0.982 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr10_-_73518772 0.970 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr4_+_71096830 0.961 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr10_+_123913094 0.948 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr12_-_14887648 0.930 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr1_-_150148608 0.857 NM_053055
THEM4
thioesterase superfamily member 4
chr2_-_96769526 0.850 NM_001142292
NM_030805
LMAN2L

lectin, mannose-binding 2-like

chr9_-_103185621 0.848 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr4_+_184257337 0.813 NM_024949
WWC2
WW and C2 domain containing 2
chr16_-_21221872 0.800 NM_001014444
NM_001888
CRYM

crystallin, mu

chr17_-_76720342 0.772 AATK
apoptosis-associated tyrosine kinase
chr4_+_9094611 0.765 NM_001040071
LOC650293
seven transmembrane helix receptor
chr11_-_35398077 0.765 NM_001195728
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr11_+_20001130 0.752 NM_001111019
NAV2
neuron navigator 2
chr3_-_172227461 0.751 NM_000340
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr3_-_56784634 0.748 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr6_+_64344307 0.740 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr7_+_47661366 0.735 NM_001123065
C7orf65
chromosome 7 open reading frame 65
chr10_-_116408046 0.732 NM_002313
ABLIM1
actin binding LIM protein 1
chr1_-_180627934 0.729 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr4_+_187424336 0.721 F11
coagulation factor XI
chr16_+_14938800 0.705 NM_006985
NPIP
nuclear pore complex interacting protein
chr3_+_46594079 0.705 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr4_+_187424111 0.689 NM_000128
F11
coagulation factor XI
chr1_+_57093030 0.687 NM_000562
C8A
complement component 8, alpha polypeptide
chr3_-_9895633 0.684 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr11_+_69165065 0.677 CCND1
cyclin D1
chr4_-_186815116 0.672 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr12_+_102859354 0.653 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr1_-_149214063 0.641 NM_022075
NM_181746
LASS2

LAG1 homolog, ceramide synthase 2

chr4_-_88076328 0.630


chr1_-_158759606 0.626 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr7_-_55897938 0.618 NM_207366
SEPT14
septin 14
chr7_+_37689903 0.601


chr6_+_64414389 0.589 NM_015153
PHF3
PHD finger protein 3
chrX_+_70255128 0.582 NM_005120
MED12
mediator complex subunit 12
chr14_+_38719462 0.574 PNN
pinin, desmosome associated protein
chr14_+_38720085 0.573 PNN
pinin, desmosome associated protein
chr14_-_94677807 0.569 NM_030621
DICER1
dicer 1, ribonuclease type III
chr7_+_1092968 0.568 NM_001039966
NM_001505
GPER

G protein-coupled estrogen receptor 1

chr4_-_186970366 0.565 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr10_+_123912930 0.555 TACC2
transforming, acidic coiled-coil containing protein 2
chr14_+_22859236 0.549 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr7_-_29152597 0.530 NM_019029
NM_031311
CPVL

carboxypeptidase, vitellogenic-like

chr10_+_101532450 0.516 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr2_+_99164064 0.509 MRPL30
mitochondrial ribosomal protein L30
chrY_-_2715478 0.509 NM_003140
SRY
sex determining region Y
chr2_-_200038055 0.507 NM_001172517
SATB2
SATB homeobox 2
chr6_+_131936057 0.505 NM_000045
ARG1
arginase, liver
chr10_-_29963906 0.499 NM_021738
SVIL
supervillin
chr2_-_188127294 0.496 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr6_+_31623370 0.487 NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr2_-_20390601 0.484 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr16_-_21344158 0.480 NM_130464
NPIPL3
nuclear pore complex interacting protein-like 3
chr7_-_1562272 0.479 NM_001097620
TMEM184A
transmembrane protein 184A
chr15_-_74941339 0.475 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr9_-_36365965 0.475 RNF38
ring finger protein 38
chr20_-_45360903 0.473 ZMYND8
zinc finger, MYND-type containing 8
chr1_+_218930542 0.471 C1orf115
chromosome 1 open reading frame 115
chrX_+_100361588 0.460 NM_001171184
NM_001939
DRP2

dystrophin related protein 2

chr20_+_30161173 0.457 TM9SF4
transmembrane 9 superfamily protein member 4
chr1_-_92144146 0.454 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr8_+_142501188 0.452 NM_007079
NM_032611
PTP4A3

protein tyrosine phosphatase type IVA, member 3

chr22_+_34025267 0.446 NM_001135729
TOM1
target of myb1 (chicken)
chr19_-_62370667 0.445 NM_001012729
DUXA
double homeobox A
chr4_-_17415918 0.433 DCAF16
DDB1 and CUL4 associated factor 16
chr5_+_76150637 0.430 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr9_-_21340885 0.425 NM_021002
IFNA6
interferon, alpha 6
chr9_-_111230926 0.422 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr1_+_81544432 0.417 LPHN2
latrophilin 2
chr3_-_79899748 0.415 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr19_-_5789740 0.411 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr3_+_157491469 0.406 NM_172159
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr9_+_96561750 0.403 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr4_+_154397975 0.401 TRIM2
tripartite motif containing 2
chr10_-_11614279 0.401 NM_001080491
USP6NL
USP6 N-terminal like
chr3_+_101720753 0.394 TMEM45A
transmembrane protein 45A
chr7_-_87180499 0.390 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr10_+_5478521 0.385 NM_005863
NET1
neuroepithelial cell transforming 1
chr3_-_195553297 0.376 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr3_-_173723754 0.375 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr12_-_368689 0.374 NM_001042603
KDM5A
lysine (K)-specific demethylase 5A
chr9_+_96528814 0.373 C9orf3
chromosome 9 open reading frame 3
chr21_-_26175068 0.372 APP
amyloid beta (A4) precursor protein
chr17_-_24425342 0.371 TIAF1
TGFB1-induced anti-apoptotic factor 1
chr6_+_167445284 0.368 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr12_-_6354650 0.365 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr3_+_149930656 0.352 NM_032049
AGTR1
angiotensin II receptor, type 1
chr15_-_81271859 0.347 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr12_+_132268067 0.336 NM_001165887
NM_003415
NM_152943
ZNF268


zinc finger protein 268


chr3_-_47909001 0.331 MAP4
microtubule-associated protein 4
chr14_-_94669547 0.331 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr18_-_59462469 0.326 NM_002974
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr18_+_44319365 0.325 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr6_+_10693964 0.321 NM_145655
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr2_-_43919392 0.320 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr16_+_2593351 0.319 LOC652276
hypothetical LOC652276
chr8_-_17599438 0.307 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr3_-_180452338 0.300 NM_171830
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr22_+_16423147 0.300 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr9_+_132579088 0.298 NM_007313
ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr10_-_97190885 0.295 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr8_+_92184022 0.293 NM_001129890
LRRC69
leucine rich repeat containing 69
chr9_+_79158164 0.293 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr2_-_20375497 0.287 PUM2
pumilio homolog 2 (Drosophila)
chr2_+_204509698 0.287 NM_012092
ICOS
inducible T-cell co-stimulator
chr10_-_42183441 0.282 LOC283027
hypothetical protein LOC283027
chr12_+_63090008 0.281 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr20_-_51633042 0.279 NM_006526
ZNF217
zinc finger protein 217
chr16_+_82540172 0.279 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr2_-_218865451 0.275 NM_022152
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr11_-_82289006 0.274 NM_005040
NM_199418
PRCP

prolylcarboxypeptidase (angiotensinase C)

chr1_+_28637247 0.272 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr20_+_56903595 0.266 GNAS
GNAS complex locus
chr1_+_144149794 0.265 NM_006472
TXNIP
thioredoxin interacting protein
chr15_+_57691272 0.264 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr3_+_63859114 0.260 NM_001177387
ATXN7
ataxin 7
chr14_+_38804226 0.256 NM_203354
CTAGE5
CTAGE family, member 5
chr19_+_21056792 0.248 NM_182515
ZNF714
zinc finger protein 714
chr1_+_67404756 0.248 NM_144701
IL23R
interleukin 23 receptor

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
38.40 5.47e-03 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
28.80 2.15e-02 GO:0047023 androsterone dehydrogenase activity
3.59 2.21e-02 GO:0001871 pattern binding
3.59 2.21e-02 GO:0030247 polysaccharide binding